Tegethoff, M., Greene, N., Olsen, J., Meyer, A. H. & Meinlschmidt, G. Maternal psychosocial stress during pregnancy and placenta weight: Evidence from a national cohort study.
The villous barrier is the physical barrier through which maternal-fetal exchange of gases, nutrients and waste occurs. Girls had larger capillary volumes per SMA-negative villi per placenta than boys (MD = 0.41: 95%CI = 0.01;0.81: P = 0.05). Cite this article. Jackson, M. R., Joy, C. F., Mayhew, T. M. & Haas, J. D. Stereological studies on the true thickness of the villous membrane in human term placentae: a study of placentae from high-altitude pregnancies. Mothers assessed their depressive symptoms at toddler follow-up with the Beck Depression Inventory-II59.
Google Scholar. Compared to other PREDO mothers, the mothers participating in this study had less depressive symptoms during the third pregnancy trimester (MD = −0.24 SD units: 95% CI = −0.45; −0.02: P = 0.03). (2019). Relationships of maternal folate and vitamin B12 status during pregnancy with perinatal depression: The GUSTO study. Elevated maternal C-reactive protein and autism in a national birth cohort. dyw154, https://doi.org/10.1093/ije/dyw154 (2016). Placenta 34, 841–845 (2013). Scale bar is 25 µm. We use cookies to help provide and enhance our service and tailor content and ads.
Novel 3D microscopic analysis of human placental villous trees reveals unexpected significance of branching angles. Studies of the dynamics of nuclear clustering in human syncytiotrophoblast.
Obstet.
J. Placenta 36, 1425–1432 (2015). Increased VSM thickness and a resulting decrease in villous membrane thickness variability has been shown in placentas from pregnancies complicated by preeclampsia26 and gestational diabetes27. Khalife, N. et al. Rev., https://doi.org/10.1016/j.neubiorev.2017.07.003 (2017). Thank you for visiting nature.com. Rep. 6, 24004 (2016). symptoms to cease physical activity immediately and consult your doctor TIME ... Elite athletes who continue to train during pregnancy require supervision by an obstetric care provider with knowledge ... www.sma.org.au • www.smartplay.com.au 03 9674 8777 Placental size is associated with mental health in children and adolescents. Proc. Maternal cortisol over the course of pregnancy and subsequent child amygdala and hippocampus volumes and affective problems. Natamba, B. K. et al.
Mayhew, T. M., Sørensen, F. B., Klebe, J. G. & Jackson, M. R. Oxygen diffusive conductance in placentae from control and diabetic women. Spinal muscular atrophy newborn screening is increasingly being used across the U.S. Higher maternal depressive symptoms throughout pregnancy (Table 2) and during each pregnancy trimester (Table 3) were associated with a significantly smaller SD of the villous barrier thickness of SMA-negative villi (indicating less villous barrier thickness variability) in unadjusted and/or adjusted regression analyses. Article Google Scholar. (2021), Psychological Medicine Psychol. We tested whether placental morphology criteria predicted toddler internalizing, externalizing and total problems using linear regression. The purpose of SMA carrier screening is to determine if a couple is at increased risk for having a child with SMA, the leading genetic cause of infant death. Res. The villous tree consists of large structural stem villi that arborize to form intermediate and terminal villi, with a γ-smooth muscle actin(SMA)-positive perivascular layer of myofibroblast-like cells that aborize in the (then myofibroblast-free and SMA-negative) peripheral part of the villous tree19. Red arrow heads label vasculo-syncytial-membrane spots. Its thickness directly correlates with exchange efficiency, thus it is a highly relevant physiological measurement. After fixation lasting at least 24 hours, the samples were routinely dehydrated in an alcohol step gradient and embedded in paraffin. Haeussner, E., Schmitz, C., Frank, H.-G. & Edler von Koch, F. Novel 3D light microscopic analysis of IUGR placentas points to a morphological correlate of compensated ischemic placental disease in humans. Pathol. Ultrastructure of Placenta of Gravidas with Gestational Diabetes Mellitus.
You could be a carrier of SMA even if no one in your family has SMA and even if you already have children without SMA.
Yet, our study has a novel focus, and its strengths include the longitudinal design, the use of validated questionnaires on maternal and toddler psychopathology39,51,52,53,54, and the repeated, fortnightly assessments of maternal antenatal depressive symptoms. Thus, an irregularity in villous barrier thickness develops and its appearance indicates optimal placental maturation. J. Clin.
Neurosci. Cross reactivity due to streptavidin use in both sequences was excluded by controls included in the second immunohistochemical sequence (anti-SMA). Placental biopsy collection was introduced to the study protocol in 2009. Räikkönen, K. et al. Disord. (A) Maternal clinically significant antenatal depressive symptoms and placental SMA-negative villi villous barrier thickness variability. If you are what you eat, then so is baby. The villous barrier thickness is expressed in micrometres. We also acknowledge the support of the British Heart Foundation. PubMed Central Chong, M. F. F. et al. Just wow.
A. Affect. Rep. 4, 6192 (2014). Psychol.
Haeussner, E. et al.
The funders had no role in the conduct or design of the study. Lond. Sci. Placenta 6, 249–58 (1985). The authors acknowledge the skilful technical assistance and diligent work of the whole team of technicians of the Department of Anatomy II (LMU) Germany, namely B. Aschauer, A. Baltruschat and B. Mosler. Spinal Muscular Atrophy (SMA) is a genetic disease affecting 1 in 10,000 live births with a carrier frequency of 1 in 50. analysed the data; all authors took part in interpreting the data, writing the manuscript and/or revising it for intellectual content. Moderate Maternal Nutrient Restriction, but not Glucocorticoid Administration, Leads to Placental Morphological Changes in the Baboon (Papio sp.). In these models, trimester-weighted mean maternal depressive symptoms across pregnancy (mean value calculated from the value in first trimester and mean values across second and third trimesters) and mean scores during each pregnancy trimester and depressive symptoms above the clinical cutoff (≥16 across pregnancy or 0, 1, or 2/3 times across pregnancy trimesters) predicted placental morphology criteria. J. 48, 28–37 (2009). University of Vermont, Research Center for … (University of Vermont, Research Center for Children, Youth, & Families, 2000).
The recently introduced 3D microscopy of peripheral villous trees48,49,50 can potentially provide this information in further studies. Article J. Physiol. Mayhew, T. M., Joy, C. F. & Haas, J. D. Structure-function correlation in the human placenta: the morphometric diffusing capacity for oxygen at full term.
In our sample, the CES-D had high internal consistency (Cronbach’s α varying from =0.85 to =0.93). However, the datasets generated during and/or analysed during the current study are available from the corresponding author on reasonable request in completely anonymized form. Assessment of young children using the Achenbach System of Empirically Based Assessment (ASEBA). Cell Biol. M.L.P. 179, 226–30 (2010). J. Further studies are needed to elucidate the contributory effects of genetic and environmental factors to our findings. Korhonen, M., Luoma, I., Salmelin, R. & Tamminen, T. A longitudinal study of maternal prenatal, postnatal and concurrent depressive symptoms and adolescent well-being.
Maternal age, pre-pregnancy body mass index (BMI), education, or history of mental disorders before pregnancy were not associated with placental morphology (P-values ≥ 0.10). By submitting a comment you agree to abide by our Terms and Community Guidelines. Screening for Depression in the General Population with the Center for Epidemiologic Studies Depression (CES-D): A Systematic Review with Meta-Analysis. Off. (B) Exemplifies a SMA-negative villus (no SMA reactivity in perivascular position). The associations with this placental morphology indicator were most consistent across analytic models for maternal depressive symptoms during the first pregnancy trimester (Table 3). Prenatal developmental origins of behavior and mental health: The influence of maternal stress in pregnancy. 136, 680–692 (2012). We found that higher maternal depressive symptoms throughout pregnancy [B = −0.24 Standard Deviation (SD) units: 95% Confidence Interval (CI) = −0.46; −0.03: P = 0.03; Mean difference = −0.66 SDs; 95% CI = −0.08; −1.23: P = 0.03; between those with and without clinically relevant depressive symptoms] were associated with lower variability in the placental villous barrier thickness of γ-smooth muscle actin-negative villi.
Depress. Aberrations in placental development and maturation that adversely affect the capacity of the placenta to provide optimal materno-fetal exchange can influence fetal health and program the fetus for disease development later in life16,17. Article PubMed Vilagut, G., Forero, C. G., Barbaglia, G. & Alonso, J. Samples were collected at two maternity clinics in Helsinki, Finland. Peroxidase with DAB as substrate (anti-CD34, brown reaction product) and β-galactosidase with X-Gal as substrate (anti-SMA, indigo-blue reaction product) were used for differential visualization in brightfield microscopy. The work was supported by the Academy of Finland, the Signe and Ane Gyllenberg Foundation, the Emil Aaltonen Foundation, EVO (a special state subsidy for health science research), the Finnish Medical Foundation, the Jane and Aatos Erkko Foundation, the Juho Vainio Foundation, MRC Career Development Award to MJC, DFG Fr1245/9–1 to HGF, the Novo Nordisk Foundation, the Päivikki and Sakari Sohlberg Foundation, the Sigrid Juselius Foundation, University of Helsinki Research Funds and the British Heart Foundation.
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